Publications

Vecchio, A.J. and Stroud R.M. (2019) “Claudin-9 structures reveal mechanisms for toxin-induced gut barrier breakdown”. Proc Natl Acad Sci USA. 116(36):17817-17824. PubMed

Vecchio A.J. and Stroud R.M. (2019) “Chapter 17: High-throughput nano-scale characterization of membrane proteins using fluorescence-detection size-exclusion chromatography”. In: Vincentelli R. (eds) High Throughput Protein Production and Purification, Methods in Molecular Biology Vol. 2025 pp. 361-388, Humana Press, NY, NY. PubMed

Lucido M.J., Orlando B.J., Vecchio, A.J., and Malkowski, M.G. (2016) “The crystal structure of aspirin acetylated human cyclooxygenase-2: insight into the formation of products with altered stereochemistry”. Biochemistry 55 (8): 1226-1238

Vecchio, A.J., Orlando, B.J., Nandagiri, R., and Malkowski, M.G. (2012) “Investigating substrate promiscuity in cyclooxygenase-2: the role of Arg-120 and residues lining the hydrophobic groove”. J. Biological Chemistry 287 (29): 24619-24630

Vecchio, A.J. and Malkowski, M.G. (2011) “The structure of NS-398 bound to cyclooxygenase-2”. J. Structural Biology 176 (2): 254-258

Vecchio, A.J. and Malkowski, M.G. (2011) “The structural basis of endocannabinoid oxygenation by cyclooxygenase-2”. J. Biological Chemistry 286 (23): 20736-20745

Dong, L., Vecchio, A.J., Sharma, N.P., Jurban, B.J., Malkowski, M.G., and Smith, W.L. (2011) “Human cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer”. J. Biological Chemistry 286 (21): 19035-19046

Vecchio, A.J., Simmons, D.M., and Malkowski, M.G. (2010) “Structural basis of fatty acid substrate binding to cyclooxygenase-2”. J. Biological Chemistry 285 (29): 22152-22163