Publications

Li, F., Egea, P.F., Vecchio, A.J., Asial, I., Gupta, M., Paulino, J., Bajaj, R., Dickinson, M.S., Ferguson-Miller, S., Monk, B.C., and Stroud, R.M. (2021) “Highlighting membrane protein structure and function: A celebration of the Protein Data Bank”. J. Biological Chemistry. 296 100557. JBC

Vecchio, A.J., Rathnayake, S.S., and Stroud, R.M. (2021) “Structural basis for Clostridium perfringens enterotoxin targeting of claudins at tight junctions in mammalian gut”. Proc Natl Acad Sci USA. 118 (15) e2024651118. PubMed

Vecchio, A.J. and Stroud, R.M. (2019) “Claudin-9 structures reveal mechanisms for toxin-induced gut barrier breakdown”. Proc Natl Acad Sci USA. 116 (36) 17817-17824. PubMed

Vecchio A.J. and Stroud, R.M. (2019) “Chapter 17: High-throughput nano-scale characterization of membrane proteins using fluorescence-detection size-exclusion chromatography”. In: Vincentelli R. (eds) High Throughput Protein Production and Purification, Methods in Molecular Biology. Vol. 2025 pp. 361-388, Humana Press, NY, NY. PubMed

Lucido M.J., Orlando B.J., Vecchio, A.J., and Malkowski, M.G. (2016) “The crystal structure of aspirin acetylated human cyclooxygenase-2: insight into the formation of products with altered stereochemistry”. Biochemistry. 55 (8): 1226-1238

Vecchio, A.J., Orlando, B.J., Nandagiri, R., and Malkowski, M.G. (2012) “Investigating substrate promiscuity in cyclooxygenase-2: the role of Arg-120 and residues lining the hydrophobic groove”. J. Biological Chemistry. 287 (29): 24619-24630

Vecchio, A.J. and Malkowski, M.G. (2011) “The structure of NS-398 bound to cyclooxygenase-2”. J. Structural Biology. 176 (2): 254-258

Vecchio, A.J. and Malkowski, M.G. (2011) “The structural basis of endocannabinoid oxygenation by cyclooxygenase-2”. J. Biological Chemistry. 286 (23): 20736-20745

Dong, L., Vecchio, A.J., Sharma, N.P., Jurban, B.J., Malkowski, M.G., and Smith, W.L. (2011) “Human cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer”. J. Biological Chemistry. 286 (21): 19035-19046

Vecchio, A.J., Simmons, D.M., and Malkowski, M.G. (2010) “Structural basis of fatty acid substrate binding to cyclooxygenase-2”. J. Biological Chemistry. 285 (29): 22152-22163